Genetics and Cancer - Ataxia Telangiectasia (A-T)
A-T is a rare childhood disease that affects the nervous system and other body systems. It may also raise the risk for breast cancer.
Genetics and Cancer - Basal Cell Nevus Syndrome (Gorlin Syndrome)
This rare syndrome raises the risk for ovarian and skin cancer. A person with this syndrome may develop two basal cell carcinomas before age 30.
Genetics and Cancer - Cowden Syndrome
The risk for breast cancer, gastrointestinal cancers, and thyroid cancer is increased with Cowden syndrome, a rare inherited disorder marked by multiple benign growths on the skin and other organs.
Genetics and Cancer - Ovarian Cancer and Hereditary Nonpolyposis Colon Cancer (HNPCC)
A woman with hereditary nonpolyposis colon cancer is at increased risk for ovarian cancer. This type of colon cancer usually is caused by mutations in one of several mismatch-repair genes.
Genetics and Cancer - Li-Fraumeni Syndrome
A person with this syndrome usually has mutations in a gene on chromosome 17 known as p53. Mutations in p53 raise the risk for early onset breast cancer, childhood sarcoma, osteosarcoma, brain tumors, leukemia, and adrenocortical carcinoma.
Genetics and Cancer - Peutz-Jeghers Syndrome
The risk for breast and ovarian cancer increased in a woman with Peutz-Jeghers syndrome. This inherited disorder is marked by dark brown or blue moles around and/or in the mouth, and around the eyes, nostrils, and anus. A woman with PJS also may have multiple polyps in the gastrointestinal tract.
Genetics and Cancer - The Genetics of Breast and Ovarian Cancer
Researchers have found specific genes associated with breast and ovarian cancers that are inherited. Certain genetic syndromes also associated with an increased risk for these cancers.
Hereditary Breast Ovarian Cancer Syndrome (BRCA1 / BRCA2)
A woman with this syndrome may develop breast cancer before age 50 and is at higher risk for developing cancer in both breasts or in both the breasts and ovaries.
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